For a similar biological approach, Organic Chemistry: A Tenth Edition by McMurry is available for free through OpenStax .
In the first step, hexokinase catalyzes the transfer of a phosphate group from ATP to the C6 hydroxyl group of glucose. This is an SN2cap S sub cap N 2 mechanism at a phosphorus atom. The Organic Chemistry Of Biological Pathways Pdf
DNA and RNA polymerases synthesize genetic strands by facilitating a nucleophilic attack. The 3'-hydroxyl group of the growing nucleotide strand acts as a nucleophile, executing a backside attack ( SN2cap S sub cap N 2 -phosphate of an incoming nucleoside triphosphate ( dNTPd cap N cap T cap P ). The pyrophosphate group ( PPicap P cap P sub i For a similar biological approach, Organic Chemistry: A
(e.g., why a certain carbonyl group is attacked), you don't have to memorize the The "Molecular Logic" of Metabolism DNA and RNA polymerases synthesize genetic strands by