Always launch the game through MO2 using the SKSE executable you configured.
Ensure you are not running the game through the Steam "Play" button. Use your mod manager (Vortex or MO2) to set skse64_loader.exe as the primary executable. skse 16640 link
If you are modding The Elder Scrolls V: Skyrim Special Edition , you have likely run into the requirement for the Skyrim Script Extender (SKSE). Specifically, version 1.6.640 corresponds to a highly stable, widely used Steam release of the game (often referred to as Anniversary Edition or AE). Always launch the game through MO2 using the
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