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These findings provide a crucial mechanistic link: NEGR1 may influence appetite, reward processing, and energy homeostasis through its effects on neurotransmitter systems in the brain. xxx netgr

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Recent studies in Negr1 -deficient mice have begun to unravel the mechanisms linking NEGR1 to body weight regulation. A 2024 study reported that (i.e., serotonin, dopamine, and norepinephrine pathways), suggesting that monoaminergic neural circuits contribute to both depressive and obesity-related phenotypes linked to the human NEGR1 gene .