The Defender real-time protection can interfere with the standard version's deep-level registry and file modifications. If you run the standard version without disabling Defender, the process will either fail or, worse, complete only partially, leaving your system in a state of partial conflict.
One saved failure event pays for 20 extra quality keys. For research labs, the value lies in reproducibility—a single retracted publication due to questionable data can cost millions in lost grants. sidchg key extra quality